Biotech vs XBI
1 of 5 biotech headliners beat XBI over the last year (4 of 5 over six months, 1 of 5 over three). Every line is measured against the benchmark itself, so the zero line is XBI.
Weekly closes through 2026-10-29. The zero line is the benchmark: a name "beats" when its total return over the window is higher than XBI's. Rebuilt every morning.
Total return
| Name | 6M | vs bench | 1Y | vs bench | 3Y | vs bench | Since |
|---|---|---|---|---|---|---|---|
| XBI benchmark | +16.7% | 0 | +44.3% | 0 | +120.0% | 0 | — |
| AMGN | +38.7% | +22.0 | +43.7% | -0.6 | +70.5% | -49.5 | 2021-10 |
| GILD | +23.6% | +6.9 | +36.6% | -7.7 | +99.0% | -21.0 | 2021-10 |
| VRTX | +25.5% | +8.8 | +31.7% | -12.6 | +43.4% | -76.6 | 2021-10 |
| REGN | +13.7% | -3.0 | +23.6% | -20.7 | -0.5% | -120.5 | 2021-10 |
| MRNA | +303.0% | +286.3 | +792.5% | +748.2 | +182.5% | +62.5 | 2021-10 |
A name whose history starts inside a window is measured from its first bar, not the window start — the "Since" column says where. Its "vs bench" (marked *) compares it with XBI over that same shorter span.
Headliners
Benchmarks available on the dashboard: XBI, IBB.
The wider biotech universe
The dashboard's Sleepers view screens these 31 lesser-covered names for the ones beating XBI on a trailing basis, with liquidity, price and coverage floors so nothing untradeable or already crowded gets through.
Other baskets
Interactive chart with 6M–5Y windows, relative / indexed / drawdown modes and the sleeper screen: Baskets tab.
How calls are checked
Every call is checked on the firm's own terms. A price target is followed until its own deadline (12 months unless the firm publishes a different horizon) and ends as reached (the stock closed at or beyond it while it stood), replaced (the same firm set a new target first) or short at deadline. A rating is compared with the stock's sector SPDR ETF on total return over the rating's life, because most big-firm ratings are relative: Overweight means "beat its peers", not "go up". Hold-type ratings are tracked, not graded. A firm is numbered only with 30+ resolved targets, and a letter prints only for a firm's whole record where an exact test separates it from a coin flip. None of this is a verdict on anyone's skill, and one day is never a grade. The full method →
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